Antibiotic In Pregnancy Pdf
.Topical Agents. Antiparasitic agents. or (after first Trimester). Short-term use after first trimester appears safe. Avoid single dose therapy (high dose). Avoid long-term use (due to fetal malformation associations).
Praziquantel - not in Briggs. (topical) - not in Briggs (1998). Anti- agents. not in Briggs (1998). Antiviral agents. not in Briggs (1998). Antibiotics.
All Antibiotics (except Moxalactam). All except Estolate. , but not (see below). All Antibiotics. (before 36 weeks).
Sulfa antibiotics (second trimester only). Antiparasitic agents. or (First Trimester). Brief use may be safe in first trimester. Antibiotics. Amikacin (Class D per manufacturer). Kanamycin.
Tobramycin (Class D per manufacturer). Sulfa (Third Trimester). All antibiotics. Does not appear to have same adverse effects as other s. May be considered in serious infections without good alternatives (e.g.
). Estolate (llosone). Due to hepatotoxicity in pregnant women.
and (Third Trimester). Do not use either of these past 36 weeks. Can cause in newborns.
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At any given time, more than 10 million women in the United States are pregnant or lactating, and exposing a fetus or newborn to antibiotics can pose a unique threat. Changes during pregnancy and lactation also can trigger pharmacokinetic and pharmacodynamic modifications that alter the effectiveness of antibiotics. Nahum and colleagues reviewed the literature on antibiotic use to provide updated, evidence-based information on antibiotic use in women who are pregnant or lactating.The researchers examined published medical literature, sources on teratogenicity and prescribing for women who are lactating or pregnant, and they abstracted data from product labels for drugs approved by the U.S.
Augmentin Antibiotic In Pregnancy
Food and Drug Administration (FDA) for use during pregnancy. The authors identified 124 references that covered 11 commonly prescribed antibiotics, all of which cross the placenta and are excreted in human breast milk.There was no teratogenic potential for penicillins G and V potassium (V-Cillink); unlikely potential for amoxicillin, chloramphenicol (Chloromycetin), ciprofloxacin (Cipro), doxycycline (Vibramycin), levofloxacin (Levaquin), and rifampin (Rifadin); and undetermined potential for clindamycin (Cleocin), vancomycin, and gentamicin. All agents were FDA Pregnancy Category B (amoxicillin, clindamycin, penicillin G, penicillin V potassium, and vancomycin) or C (chloramphenicol, ciprofloxacin, gentamicin, levofloxacin, and rifampin), except for doxycycline, which was category D.Evidence suggested that increased maternal dose or shorter dosing intervals should be considered for amoxicillin, gentamicin, and penicillins G and V potassium. However, information on pharmacokinetics during pregnancy was inadequate for the other antibiotics. There were limited data on several other aspects of antibiotic use during pregnancy, but the authors stress that conducting studies in this area would be challenging.Despite the lack of scientific evidence, the authors conclude that physicians should make balanced judgments about the well-being of the mother and her child before making decisions about antibiotic use during pregnancy and lactation.
Antibiotic In Pregnancy
Relative Risk of Human Teratogenic Risk Associated with Antibiotic Use in Pregnancy and Lactation AntibioticTeratogenicity risk/data availableFDA Pregnancy CategoryAmoxicillinUnlikely/fairBChloramphenicol (Chloromycetin)Unlikely/fairCCiprofloxacin (Cipro)Unlikely/fairCClindamycin (Cleocin)Undetermined/limitedBDoxycycline (Vibramycin)Unlikely/fairDGentamicinUndetermined/limitedCLevofloxacin (Levaquin)Unlikely/fairCPenicillin GNone/goodBPenicillin V potassium (V-Cillink)None/goodBRifampin (Rifadin)Unlikely/limited to fairCVancomycinUndetermined/very limitedB. Relative Risk of Human Teratogenic Risk Associated with Antibiotic Use in Pregnancy and Lactation AntibioticTeratogenicity risk/data availableFDA Pregnancy CategoryAmoxicillinUnlikely/fairBChloramphenicol (Chloromycetin)Unlikely/fairCCiprofloxacin (Cipro)Unlikely/fairCClindamycin (Cleocin)Undetermined/limitedBDoxycycline (Vibramycin)Unlikely/fairDGentamicinUndetermined/limitedCLevofloxacin (Levaquin)Unlikely/fairCPenicillin GNone/goodBPenicillin V potassium (V-Cillink)None/goodBRifampin (Rifadin)Unlikely/limited to fairCVancomycinUndetermined/very limitedB.